The effect of pioglitazone on performance and plasma lipids of post-peak female broiler breeders

نوع مقاله : مقاله پژوهشی

نویسندگان

Department of Animal Science, College of Agriculture and Natural Resources, University of Tehran, Karaj, Iran

چکیده

مقدمه: تجمع زیادی تری­گلیسرید و اسیدهای چرب در سلول­های غیر چربی منجر به مسمومیت چربی، عملکرد ناقص سلولی و مرگ سلولی می­شود. گرچه محدودیت خوراکی یک ابزار مدیریتی عملی و کارآمد برای پیشگیری از چاقی در مرغ­های مادر است، با این وجود بعد از اوج تولید مرغ­ها تمایل به افزایش وزن دارند. مسمومیت چربی در سلول­های کبدی و سلول­های فولیکولی مرغ­های تخمگذار می­تواند باعث عملکرد ناقص کبد، ناهنجاری­های تخمدانی و نهایتاً کاهش تولید تخم­مرغ شود. هدف: این مطالعه برای تعیین اثر پیوگلیتازون روی تولید تخم­مرغ و فراسنجه­های خونی مرغ­های مادر گوشتی انجام شد. مواد و روش­ها: بنابراین، 40 پرنده از سن 45 تا 51 هفتگی به طور تصادفی به چهار گروه تیماری تقسیم شدند و جیره پایه­ای که سطوح مختلف پیوگلیتازون (0، 10، 20 و 40 میلی­گرم/پرنده/روز) را داشت به مرغ­ها تغذیه شد. نتایج: نتایج نشان داد که سطوح 20 و 40 میلی­گرم، تولید و کیفیت تخم­مرغ را بهبود می­بخشد (05/0p <). از لحاظ لیپیدهای پلاسمایی، پیوگلیتازون در سطوح 20 و 40 میلی­گرم اثرات هایپولیپمیک داشت و توانست غلظت گلوکز، تری­گلیسرید، لیپوپروتئین کم چکال و کلسترول را کاهش دهد (05/0p <). همچنین، فعالیت آنزیم­های کبدی (معیاری از سلامت کبد) نیز در مرغ­های دریافت کننده 20 و 40 میلی­گرم پیوگلیتازون بهبود یافت (05/0p <). علاوه بر این، مشاهدات کالبدشکافی نشان داد که وزن کبد و چربی شکمی به طور معنی­داری با افزودن 20 و 40 میلی­گرم پیوگلیتازون به جیره هر مرغ کاهش می­یابد (05/0p <). نتیجه­گیری نهایی: براساس نتایج این پژوهش، پیوگلیتازون در سطوح 20 و 40 میلی­گرم/پرنده/روز از طریق کم کردن لیپیدهای پلاسما، می­تواند عملکرد مرغ­های مادر را پس از اوج تولید بهبود بخشد.

کلیدواژه‌ها

عنوان مقاله [English]

The effect of pioglitazone on performance and plasma lipids of post-peak female broiler breeders

نویسندگان [English]

  • M Heidari Amaleh
  • A Zare Shahneh
  • M Zaghari
چکیده [English]

Introduction: The accumulation of excess triacylglycerol and fatty acids in nonadipocytes results in lipotoxicity, cellular dysfunction, and cell death. Although feed restriction is an effective and practical management technique to prevent the obesity in broiler breeders, after the peak of egg production hens have propensity to be overweight. Lipotoxicity in hepatocytes and follicular cells of laying hens could cause liver disfunction, ovarian abnormalities, and therefore, decline egg production. Aim: This study was conducted to determine the effect of Pioglitazone on egg production and plasma metabolites in broiler breeder hens. Material and method:  Thus, forty birds were randomly allotted to four groups with 10 birds in each and were fed standard diet supplemented with different levels of Pioglitazone at 0, 10, 20 and 40 mg/bird per day from 45 through to 51 weeks of age. Results: The results indicated that 20 and 40 mg levels improved egg production and quality (p < 0.05). In regard to plasma lipids, Pioglitazone at levels of 20 and 40 mg had hypolipemic effects and could effectively decrease plasma glucose, triacylglycerol, low density lipoprotein and cholesterol (p < 0.05). In addition, the activity of liver enzymes, as a criterion of liver health, was improved in hens receiving 20 and 40 mg Pioglitazone (p < 0.05). Also, necropsy observations showed that liver and abdominal fat weights significantly decreased by dietary supplementation of 20 and 40 mg Pioglitazone (p < 0.05). Conclusion: In conclusion, the current study indicated that Pioglitazone at levels 20 and 40 mg/bird/day could improve performance of post-peak female broiler breeders through lowering plasma lipids.

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پژوهش های علوم دامی (دانش کشاورزی)
دوره 29، شماره 2
شهریور 1398
صفحه 141-151

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  • تاریخ دریافت: 21 آبان 1398
  • تاریخ پذیرش: 21 آبان 1398

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