The effect of pioglitazone on performance and plasma lipids of post-peak female broiler breeders

Document Type : Research Paper

Authors

Abstract

Introduction: The accumulation of excess triacylglycerol and fatty acids in nonadipocytes results in lipotoxicity, cellular dysfunction, and cell death. Although feed restriction is an effective and practical management technique to prevent the obesity in broiler breeders, after the peak of egg production hens have propensity to be overweight. Lipotoxicity in hepatocytes and follicular cells of laying hens could cause liver disfunction, ovarian abnormalities, and therefore, decline egg production. Aim: This study was conducted to determine the effect of Pioglitazone on egg production and plasma metabolites in broiler breeder hens. Material and method:  Thus, forty birds were randomly allotted to four groups with 10 birds in each and were fed standard diet supplemented with different levels of Pioglitazone at 0, 10, 20 and 40 mg/bird per day from 45 through to 51 weeks of age. Results: The results indicated that 20 and 40 mg levels improved egg production and quality (p < 0.05). In regard to plasma lipids, Pioglitazone at levels of 20 and 40 mg had hypolipemic effects and could effectively decrease plasma glucose, triacylglycerol, low density lipoprotein and cholesterol (p < 0.05). In addition, the activity of liver enzymes, as a criterion of liver health, was improved in hens receiving 20 and 40 mg Pioglitazone (p < 0.05). Also, necropsy observations showed that liver and abdominal fat weights significantly decreased by dietary supplementation of 20 and 40 mg Pioglitazone (p < 0.05). Conclusion: In conclusion, the current study indicated that Pioglitazone at levels 20 and 40 mg/bird/day could improve performance of post-peak female broiler breeders through lowering plasma lipids.

References

Aghamohammadzadeh N, Niafar M, Dalir Abdolahinia E, Najafipour F, Mohamadzadeh Gharebaghi S, Adabi K and Ahadi H, 2015. The effect of pioglitazone on weight, lipid profile and liver enzymes in type 2 diabetic patients. Therapeutic Advances in Endocrinology and Metabolism 6(2): 56-60.
Aviagen, 2013. Parent stock management handbook: Ross 308. Newbridge, UK.
Bajaj M, Baig R, Suraamornkul S, Hardies LJ, Coletta DK, Cline GW, Monroy A, Koul S, Sriwijitkamol S, Musi,N, Shulman G and DeFronzo RA, 2010. Effects of pioglitazone on intramyocellular fat metabolism in patients with type 2 diabetes mellitus. The Journal of Clinical Endocrinology and Metabolism 95(4): 1916-1923.
Belfort R, Harrison SA, Brown K, Darland C, Finch J, Hardies J, Balas B, Gastaldelli, Tio F, Pulcini J, Berria R, Ma JZ, Dwivedi S, Havranek R, Fincke C, DeFronzo R, Bannayan GA, Schenker S and Cusi K, 2006. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. The New England Journal of Medicine 355(22): 2297-2307.
Bennion NL and Warren DC, 1933. Some factors affecting egg size in the domestic fowl. Poultry Science 12(6): 362-367.
Betteridge DJ, 2007. Effects of pioglitazone on lipid and lipoprotein metabolism. Diabetes, Obesity and Metabolism 9(5): 640-647.
Butler EJ, 1976. Fatty liver diseases in the domestic fowl-A review. Avian Pathology 5(1): 1-14.
Chen SE, McMurtry JP and Walzem RL, 2006. Overfeeding-induced ovarian dysfunction in broiler breeder hens is associated with lipotoxicity. Poultry Science 85(1): 70-81.
Chen WL, Wei HW, Chiu WZ, Kang CH, Lin TH, Hung CC, Chen MC, Shieh MS, Lee CC and Lee HM, 2011. Metformin regulates hepatic lipid metabolism through activating AMP-activated protein kinase and inducing ATGL in laying hens. European Journal of Pharmacology 671(1): 107-112. 
Clark M, Thomaseth K, Dirikolu L, Ferguson DC and Hoenig M, 2014. Effects of pioglitazone on insulin sensitivity and serum lipids in obese cats. Journal of Veterinary Internal Medicine 28(1): 166-174.
Clark RB, 2002. The role of PPARs in inflammation and immunity. Journal of Leukocyte Biology 71(3): 388-400.
Ferre P, 2004. The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. Diabetes 53(1): 43-50.
Fujioka S, Matsuzawa Y, Tokunaga K and Tarui S, 1987. Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism 36(1): 54-59.
Giannini EG, Testa R and Savarino V, 2005. Liver enzyme alteration: a guide for clinicians. Canadian Medical Association Journal 172(3): 367-379.
Glueck CJ, Moreira A, Goldenberg N, Sieve L and Wang P, 2003. Pioglitazone and metformin in obese women with polycystic ovary syndrome not optimally responsive to metformin. Human Reproduction 18(8): 1618-1625.
Haugh RR, 1937. The Haugh Unit for Measure of Egg Quality. U. S. Egg & Poultry Magazine 43: 552-555.
Hermier D, 1997. Lipoprotein metabolism and fattening in poultry. Journal of Nutrition 127(5 Suppl): 805S-808S.
Hussian M, Arain AQ and Chiragh S, 2016. Pioglitazone improves serum lipid profile in diet induced hyperlipidaemic non diabetic rats. Journal of Pakistan Medical Association 66(10): 1286-1290.
Ibáñez L, López-Bermejo A, del Rio L, Enríquez G, Valls C and de Zegher F, 2007. Combined low-dose pioglitazone, flutamide, and metformin for women with androgen excess. The Journal of Clinical Endocrinology & Metabolism 92(5): 1710-1714.
Imamoto E, Yoshida N, Uchiyama K, Kuroda M, Kokura S, Ichikawa H, Naito Y, Tanigawa T and Yoshikawa T, 2004. Inhibitory effect of pioglitazone on expression of adhesion molecules on neutrophils and endothelial cells. Biofactors 20(1): 37-47.
Ji B, Ernest B, Gooding J, Das S, Saxton A, Simon J, Dupont J, Metayer-Coustard S and Campagna SR, Voy B, 2012. Transcriptomic and metabolomic profiling of chicken adipose tissue in response to insulin neutralization and fasting. BMC Genomics 13(1): 441.
Jull MA, 1924. Egg weight in relation to productionpart i. The relationship of the weights of the parts of the egg to the total egg weight. Poultry Science 3(3): 77-88.
Kajita K, Mori I, Hanamoto T, Ikeda T, Fujioka K, Yamauchi M, Okada H, Usui T, Takahashi N., kitada Y, Taguchi K, Kajita T, Uno Y, Morita H and Ishizuka T, 2012. Pioglitazone enhances small-sized adipocyte proliferation in subcutaneous adipose tissue. Endocrine Journal 59(12): 1107-1114.
Leeson S, Summers JD, 2000. Broiler Breeder Production. University Books, Guelph, Ontario, Canada. 184 pp.
Liu ZC, Su CM, Xie YL, Chang CJ, Chen JY, Wu SW, Chen YH, Walzem RL, Huang SY and Chen SE, 2016. Intracellular lipid dysregulation interferes with leukocyte function in the ovaries of meat-type hens under unrestricted feed intake. Animal Reproduction Science 167: 40-50.
Liu ZC, Xie YL, Chang CJ, Su CM, Chen YH, Huang SY and Chen SE, 2014. Feed intake alters immune cell functions and ovarian infiltration in broiler hens: implications for reproductive performance. Biology of Reproduction 90(6): 134, 1-8.
Miyazaki Y, Mahankali A, Matsuda M, Mahankali S, Hardies J, Cusi K, Mandarino LJ and DeFrronnzo RA, 2002. Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients. The Journal of Clinical Endocrinology and Metabolism 87(6): 2784-2791.
Mori AV, Mendonça CX and Santos COF, 1999. Effect of dietary lipid-lowering drugs upon plasma lipids and egg yolk cholesterol levels of laying hens. Journal of Agricultural and Food Chemistry 47(11): 4731-4735.
Nestler JE, Stovall D, Akhter N, Iuorno MJ and Jakubowicz DJ, 2002. Strategies for the use of insulin-sensitizing drugs to treat infertility in women with polycystic ovary syndrome. Fertility and Sterility 77(2), 209-215.
Pan YE, Liu ZC, Chang CJ, Huang YF, Lai CY, Walzem RL and Chen SE, 2014. Feed restriction ameliorates metabolic dysregulation and improves reproductive performance of meat-type country chickens. Animal Reproduction Science 151(3-4): 229-236.
Pan YE, Liu ZC, Chang CJ, Xie YL, Chen CY, Chen CF, Walzem RL and Chen SE, 2012. Ceramide accumulation and up-regulation of proinflammatory interleukin-1beta exemplify lipotoxicity to mediate declines of reproductive efficacy of broiler hens. Domestic Animal Endocrinology 42(3): 183-194.
Rasouli N, Raue U, Milers LM, Lu T, Di Gregorio GB, Elbein SC and Kern PA, 2005. Pioglitazone improves insulin sensitivity through reduction in muscle lipid and redistribution of lipid into adipose tissue. American Journal of Physiology and Endocrinology Metabolism 288(5): E930-4.
Richards MP and Proszkowiec-Weglarz M, 2007. Mechanisms regulating feed intake, energy expenditure, and body weight in poultry. Poultry Science 86(7): 1478-1490.
Robinson FE, Wilson JL, Yu MW, Fasenko GM and Hardin RT, 1993. The relationship between body weight and reproductive efficiency in meat-type chickens. Poultry Science 72(5): 912-922.
Roque L and Soares MC, 1994. Effects of eggshell quality and broiler breeder age on hatchability. Poultry Science 73(12): 1838-1845.
Sangeeta S, 2012. Metformin and pioglitazone in polycystic ovarian syndrome: a comparative study. Journal of Obstetrics and Gynaecology of India 62(5): 551-556.
Sanyal AJ, Chalasani N, Kowdley KV, McCullough A, Diehl AM, Bass NM, Neuschwander-Tetri BA, Lavine JE, Tonascia J, Unalp A, Van Natta M, Clark J, Brunt EM, Kleiner DE, Hoofnagle JH and Robuck PR, 2010. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. New England Journal of Medicine 362(18): 1675-1685.
Scheen AJ, Esser N and Paquot N, 2015. Antidiabetic agents: Potential anti-inflammatory activity beyond glucose control. Diabetes & Metabolism 41(3): 183-194.
Smith U, 2001. Pioglitazone: mechanism of action. International Journal of Clinical Practice Supplement 121: 13-18.
Spiegelman BM, 1998. PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. Diabetes 47(4): 507-514.
Stumvoll M, 2003. Thiazolidinediones - some recent developments. Expert Opinion on Investigational Drugs 12(7): 1179-1187.
Thomas EL, Potter E, Tosi I, Fitzpatrick J, Hamilton G, Amber V, Hughes R, North C, Holnoet P, Seed M, Betteridge DJ, Bell JD and Naoumova RP, 2007. Pioglitazone added to conventional lipid-lowering treatment in familial combined hyperlipidaemia improves parameters of metabolic control: relation to liver, muscle and regional body fat content. Atherosclerosis 195(1): e181-190.
Trott KA, Giannitti F, Rimoldi G, Hill A, Woods L, Barr B and Mete A, 2013. Fatty liver hemorrhagic syndrome in the backyard chicken: a retrospective histopathologic case series. Veterinary Pathology 51(4): 787-795.
Unger RH, 2002. Lipotoxic Diseases. Annual Review of Medicine 53(1): 319-336.
Vidal-Puig AJ, Considine RV, Jimenez-Linan M, Werman A, Pories WJ, Caro JF and Flier JS, 1997. Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids. Journal of Clinical Investigation 99(10): 2416-2422.
Walzem RL and Chen SE, 2014. Obesity-induced dysfunctions in female reproduction: lessons from birds and mammals. Advances in Nutrition 5(2): 199-206.
Walzem RL, Simon C, Morishita T, Lowenstine L and Hansen RJ, 1993. Fatty liver hemorrhagic syndrome in hens overfed a purified diet. Selected enzyme activities and liver histology in relation to liver hemorrhage and reproductive performance. Poultry Science 72(8): 1479-1491.
Wei Z, Li P, Huang S, Lkhagvagarav P, Zhu M, Liang C and Jia C, 2019. Identification of key genes and molecular mechanisms associated with low egg production of broiler breeder hens in ad libitum. BMC Genomics 20(1):408-416.
Wu CW, Chu ESH, Lam CNY, Cheng ASL, Lee CW and Wong VWS, Yu J, 2010. PPARgamma is essential for protection against nonalcoholic steatohepatitis. Gene Therapy 17(6): 790-798.
Xie YL, Pan YE, Chang CJ, Tang PC, Huang YF, Walzem RL and Chen SE, 2012. Palmitic acid in chicken granulosa cell death-lipotoxic mechanisms mediate reproductive inefficacy of broiler breeder hens. Theriogenology 78(9): 1917-1928.
Yki-Järvinen H, 2004. Thiazolidinediones. New England Journal of Medicine 351(11): 1106-1118.
Yousefi A, Kohram H, Zare Shahneh A, Zamiri MJ, Fouladi-Nashta A, 2016. Effects of dietary supplementation of pioglitazone on metabolism, milk yield, and reproductive performance in transition dairy cows. Theriogenology 85(9): 1540-1548.
Yu MW, Robinson FE, Charles RG and Weingardt R, 1992. Effect of feed allowance during rearing and breeding on female broiler breeders. 2. Ovarian morphology and production. Poultry Science 71(10): 1750-1761.
Zhang XY, Wu MQ, Wang SZ, Zhang H, Du ZQ, Li YM, Cao ZP, Luan P, Leng L and Li H, 2018. Genetic selection on abdominal fat content alters the reproductive performance of broilers. Animal 12(6):1232-1241.
Animal Science Research
Volume 29, Issue 2
November 2019
Pages 141-151

Files

History

  • Receive Date: 12 November 2019
  • Accept Date: 12 November 2019

Share

How to cite

Statistics